formulation, characterization and optimization of liposomes containing eicosapentaenoic and docosahexaenoic acids; a methodology approach
نویسندگان
چکیده
omega-3 fatty acids (fas) have been shown to prevent cardiovascular disease. the most commonly used omega-3 fatty acids like eicosapentaenoic acid (epa) and docosahexaenoic acid (dha) are highly vulnerable to oxidation and therefore, have short shelf life. recent advances in nanoliposomes provided a biocompatible system for stabilizing omega-3 fas. several methods could be implemented to prepare nanoliposomes. to the best of our knowledge, the performances of these methods in preparation omega-3 fas have not been examined. nanoliposomes were prepared by thin film hydration followed by one of the following methods: 1- extrusion, ultrasonic irradiation; 2- bath sonication; 3- probe sonication; or 4- combined probe and bath sonication. the size of liposomes obtained from methods 1 to 4 were 99.7 ± 3.5, 381.2 ± 7.8, 90.1 ± 2.3, and 87.1± 4.10 nm with ξ potential being -42.4 ± 1.7, -36.3 ± 1.6, -43.8 ± 2.4, and 31.6 ± 1.9 mv, respectively. the encapsulation efficiency (ee) for dha was 13.2 ± 1.1%, 26.7 ± 1.9%, 56.9 ± 5.2%, and 51.8 ± 3.8% for methods 1 to 4, respectively. the corresponding levels for epa were 6.5 ± 1.3%, 18.1 ± 2.3%, 38.6 ± 1.8%, and 38 ± 3.7%, respectively. the ee for dha and epa of liposomes for both methods 3 and 4 increased significantly (p < 0.05). propanal, as the major volatile product formed during liposomal preparations, amounts from 81.2 ± 4.1 to 118.8 ± 2.3 µgg-1.
منابع مشابه
Formulation, Characterization and Optimization of Liposomes Containing Eicosapentaenoic and Docosahexaenoic acids; A Methodology Approach
Omega-3 fatty acids (FAs) have been shown to prevent cardiovascular disease. The most commonly used omega-3 fatty acids like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are highly vulnerable to oxidation and therefore, have short shelf life. Recent advances in nanoliposomes provided a biocompatible system for stabilizing omega-3 FAs. Several methods could be implemented to prepar...
متن کاملFormulation, Characterization and Optimization of Liposomes Containing Eicosapentaenoic and Docosahexaenoic acids; A Methodology Approach
Omega-3 fatty acids (FAs) have been shown to prevent cardiovascular disease. The most commonly used omega-3 fatty acids like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are highly vulnerable to oxidation and therefore, have short shelf life. Recent advances in nanoliposomes provided a biocompatible system for stabilizing omega-3 FAs. Several methods could be implemented to prepar...
متن کاملFormulation, Characterization and Optimization of Liposomes Containing Eicosapentaenoic and Docosahexaenoic Acids; A Methodology Approach
Omega-3 fatty acids (FAs) have been shown to prevent cardiovascular disease. The most commonly used omega-3 fatty acids like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are highly vulnerable to oxidation and therefore, have short shelf life. Recent advances in nanoliposomes provided a biocompatible system for stabilizing omega-3 FAs. Several methods could be implemented to prepar...
متن کاملpreparation, characterization and optimization of liposomes containing eicosapentaenoic and docosahexaenoic acids; a methothodology approach
متن کامل
synthesis and characterization of some new cyclometalated organoplatinum(ii) complexes containing phosphite ligand
در این تحقیق روشی جهت سنتز یک سری از کمپلکس های پلاتین (ii) حاوی لیگاند های دهنده ی فسفری شامل فسفیت و فسفین ارائه شده است. واکنش پیش ماده ی پلاتین (ii)،trans/cis- [ptcl2(sme2)2] ، با 2 اکی مولار از لیگاند p(oph)3در حلال بنزن کمپلکس1، cis-[ptcl2(p(oph)3)2] را تولید می نماید. جهت سنتز کمپلکس سایکلو متال فسفیتی، کمپلکس 1 با 1 اکی والان واکنشگر ptcl2 در حلال زایلن در شرایط رفلاکس زیر گاز آرگون م...
preparation and characterization of new co-fe and fe-mn nano catalysts using resol phenolic resin and response surface methodology study for fischer-tropsch synthesis
کاتالیزورهای co-fe-resol/sio2و fe-mn-resol/sio2 با استفاده از روش ساده و ارزان قیمت همرسوبی تهیه شدند. از رزین پلیمری resol در فرآیند تهیه کاتالیزور استفاده شد.
منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of pharmaceutical researchجلد ۱۳، شماره ۲، صفحات ۳۹۳-۴۰۴
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023